You’ve probably heard of cannabinoids, particularly the most famous ones, THC and CBD. While cannabidiol (CBD) and tetrahydrocannabinol (THC) are two of the most popular phytocannabinoids on the market today, scientists are constantly discovering new ones. To date, around 140 different cannabinoids have been recognized. But you’ve probably never heard of cannabichromene (CBC). CBC, discovered over 56 years ago. Although it does not receive as much attention, the effects of CBC are quite promising. THC and CBD derive from cannabigerolic acid, which is whence CBC gets its name (CBGA). CBGA is produced by cannabis plants and is a precursor to three primary cannabinoids: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA). CBC is a key phytocannabinoid that is significantly underappreciated. Despite the lack of studies, CBC has shown promise in pain treatment, mood enhancement, and neuroprotection. It’s also non-psychoactive. Continue reading to learn more about CBC and what CBC cannabinoid do!
What Is CBC?Cannabichromene, or CBC for short, is a non-intoxicating, legal cannabinoid found in marijuana and hemp. Along with cannabidiol, CBC is a significant phytocannabinoid (CBD). Although this name may be unfamiliar to some, it has been used in the scientific community for 56 years. Dr. Raphael Mechoulam and Y. Gaoni discovered it in 1966. Like any other phytocannabinoid, such as cannabidiol (CBD), CBC originates organically from the same component found within the hemp plant. Cannabigerolic acid (CBGA), the mother of all cannabinoids, is the “source” chemical. CBC is one of the common non-psychotropic found in Cannabis strains or kinds. CBC has been demonstrated to interact with TRP cation channels such as TRPA1, TRPV1–4, and TRPV8. CBC can be used to create tincture oils as well as other hemp-based therapeutic items like cartridges and edibles. It is also widely linked to pain relief, increased mood, and neuroprotection. However, research into the advantages of CBC is currently limited.
What Does CBC Cannabinoid Do?CBC differs from other cannabinoids in its mode of action. Most cannabinoids bind with CB1 or CB2 receptors in the endocannabinoid system, enhancing endocannabinoid synthesis. According to preliminary research, CBC has a higher chance of interacting with receptor sites such as TRPV1 than CBD. CBC is also a selective CB2 receptor agonist, making it more efficient in hyperpolarizing AtT20 cells than THC. With these qualities, CBC has the potential to be a useful analgesic. These receptor sites are known as transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPAN1) (TRPA1). They may appear unusual and unfamiliar, but you may be familiar with the experience of dealing with just one of them.
As previously stated, CBC interacts with receptor sites such as TRPV1, which are involved in inflammation and pain sensitivity. Aside from taste buds, these receptors can be found on various cells, including nerve cells. They are easily irritated by stimuli like heat, acidity, pressure, and other irritants. The rat paw edema test and the erythrocyte membrane stabilization assay were used to test CBC in vivo and in vitro.